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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...
Adherens Junctions01:24

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types –  adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as  epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as  heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...

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Related Experiment Video

Updated: Jun 1, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

Immunity and adhesion-GPCRs.

Simon Yona, Hsi-Hsien Lin, Martin Stacey

    Advances in Experimental Medicine and Biology
    |May 31, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Adhesion-GPCRs, a unique receptor family, are crucial for immune responses. This study highlights immunological insights into EGF-TM7 subfamily proteins and their role in coordinating innate and acquired immunity.

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    Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
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    Published on: October 17, 2014

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    Last Updated: Jun 1, 2026

    Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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    Published on: June 13, 2014

    Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
    08:27

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    Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
    08:15

    Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules

    Published on: October 17, 2014

    Area of Science:

    • Molecular Biology
    • Immunology
    • Cell Biology

    Background:

    • Adhesion-GPCRs possess a unique structure with large extracellular domains.
    • These receptors are widely expressed but tightly regulated, often cell-type specific.
    • The EGF-TM7 subfamily, expressed by leukocytes, is key in immune response coordination.

    Purpose of the Study:

    • To provide immunological insights into EGF-TM7 proteins.
    • To explore the broader role of adhesion-GPCRs in immunity.
    • To highlight the function of specific adhesion-GPCR subfamily members.

    Main Methods:

    • Literature review and synthesis of existing research.
    • Analysis of protein structure and expression patterns.
    • Focus on immunological functions of EGF-TM7 and related adhesion-GPCRs.

    Main Results:

    • Adhesion-GPCRs exhibit diverse protein modules in their extracellular regions.
    • EGF-TM7 subfamily members play a significant role in leukocyte function.
    • These receptors are integral to both innate and acquired immune system coordination.

    Conclusions:

    • Adhesion-GPCRs, particularly EGF-TM7, are vital for immune system regulation.
    • Understanding these receptors offers insights into immune response mechanisms.
    • Further research into adhesion-GPCRs can advance immunological knowledge.