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Related Experiment Video

Updated: Jun 1, 2026

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Evaluation of Cerebral Blood Flow Autoregulation in the Rat Using Laser Doppler Flowmetry

Published on: January 19, 2020

Autoregulatory mechanisms controlling the Microprocessor.

Robinson Triboulet¹, Richard I Gregory

¹Stem Cell Program, Children's Hospital Boston, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Harvard Stem Cell Institute, Boston, Massachusettes 02115, USA.

Advances in Experimental Medicine and Biology

|June 2, 2011

Summary

This summary is machine-generated.

The Microprocessor complex, crucial for miRNA biogenesis, is regulated by a feedback loop involving DGCR8 mRNA processing. This mechanism ensures Microprocessor integrity and controls microRNA production.

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Last Updated: Jun 1, 2026

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Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

The Microprocessor complex, containing Drosha and DGCR8, initiates microRNA (miRNA) biogenesis by cleaving pri-miRNAs.
Dysregulation of the Microprocessor is linked to various human diseases, highlighting the need to understand its regulation.

Purpose of the Study:

To elucidate the regulatory mechanisms controlling Microprocessor subunit expression.
To investigate a newly identified post-transcriptional regulatory mechanism governing Microprocessor activity.

Main Methods:

Analysis of post-transcriptional regulation of Microprocessor subunits.
Investigating the role of DGCR8 in Drosha protein stabilization.

Main Results:

A post-transcriptional feedback loop involving Microprocessor-mediated processing of DGCR8 mRNA was uncovered.
DGCR8 plays a role in stabilizing Drosha protein.

Conclusions:

The Microprocessor complex regulates its own integrity through a feedback loop involving DGCR8 mRNA processing.
This regulatory mechanism, including DGCR8's role in Drosha stabilization, is critical for controlling Microprocessor activity and miRNA biogenesis.