Meta-analysis of wavefront-guided vs. wavefront-optimized LASIK for myopia

Area of Science:

• Ophthalmology
• Refractive Surgery
• Corneal Surgery

Background:

• Laser in situ keratomileusis (LASIK) is a common procedure for myopia correction.
• Wavefront technology aims to improve visual outcomes by analyzing individual eye aberrations.

Purpose of the Study:

• To compare clinical outcomes between wavefront-guided LASIK and wavefront-optimized LASIK for myopia treatment.
• To evaluate differences in visual acuity, refractive accuracy, and higher-order aberrations.

Main Methods:

• A meta-analysis of seven studies involving 930 eyes was conducted.
• Literature search included Cochrane Library, MEDLINE, and EMBASE.
• Statistical analysis was performed using RevMan 5.0 software.

Main Results:

• No significant differences were found in achieving 20/20 or better uncorrected visual acuity or refractive targets within ±0.50 D.
• No patients lost two or more lines of corrected distance visual acuity.
• Wavefront-guided LASIK showed a significantly better postoperative aberration profile in patients with preoperative higher-order aberrations >0.3 μm RMS.

Conclusions:

• Both wavefront-guided and wavefront-optimized LASIK demonstrate excellent efficacy, safety, and predictability.
• Wavefront-guided LASIK may be preferable for patients with higher preoperative higher-order aberrations (>0.3 μm RMS).