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Enamine carboxylates as stereodetermining intermediates in prolinate catalysis

Jason E Hein1, Jordi Burés, Yu-hong Lam

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

Organic Letters
|October 1, 2011
PubMed
Summary

Studies on aldehyde alpha-amination with prolinate salts reveal an enamine carboxylate intermediate. This intermediate is key in the stereodetermining step of the reaction mechanism.

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