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Updated: May 28, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Heart failure and cognitive function in the general population: the Hoorn Study.

Katja van den Hurk¹, Yael D Reijmer, Esther van den Berg

¹Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Van der Boechorststraat 7, Amsterdam, The Netherlands.

European Journal of Heart Failure

|October 13, 2011

Summary

Reduced cognitive functioning, including attention and executive skills, is linked to early stages of left ventricular (LV) dysfunction and heart failure. Brain natriuretic peptide (BNP) may be a key indicator for cognitive decline.

Related Experiment Videos

Last Updated: May 28, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Area of Science:

Cardiology
Neuroscience
Gerontology

Background:

Cardiovascular diseases, including heart failure, are increasingly prevalent in aging populations.
Cognitive decline is a significant concern in older adults, impacting quality of life.
The relationship between early cardiac dysfunction and cognitive impairment requires further elucidation.

Purpose of the Study:

To investigate the association between early left ventricular (LV) dysfunction and cognitive functioning.
To determine if markers of cardiac health predict cognitive performance in older adults.
To explore the role of brain natriuretic peptide (BNP) in cognitive decline.

Main Methods:

Longitudinal study of 313 non-demented older adults (59-87 years) from the Hoorn Study.
Echocardiography assessed LV systolic and diastolic function at baseline and follow-up.
Cognitive tests evaluated information processing speed, memory, attention, and executive functioning; BNP levels were measured.

Main Results:

Baseline LV diastolic function, not systolic function, correlated with lower attention and executive functioning scores at follow-up.
Elevated baseline and follow-up brain natriuretic peptide (BNP) levels were associated with poorer performance across all cognitive domains.
Individuals with heart failure at follow-up exhibited significantly lower attention and executive functioning scores.

Conclusions:

Early-stage left ventricular dysfunction and heart failure are associated with measurable deficits in cognitive functioning.
Brain natriuretic peptide (BNP) emerges as a potential biomarker and risk factor for cognitive decline in the general population.
These findings highlight the interconnectedness of cardiovascular and cognitive health in aging individuals.