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Updated: May 25, 2026

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

Efficient palladium-catalyzed cross-coupling of highly acidic substrates, nitroacetates

Alison E Metz1, Simon Berritt, Spencer D Dreher

  • 1Penn Merck High Throughput Experimentation Laboratory, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 1910-6323, USA.

Organic Letters
|January 24, 2012
PubMed
Summary

New palladium-catalyzed methods efficiently create 2-aryl-2-nitroacetates. This reaction couples aryl bromides with acidic nitroacetates, offering a streamlined synthetic route.

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