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Closed-loop artificial pancreas: current studies and promise for the future.
1Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA. stuart.weinzimer@yale.edu
Current Opinion in Endocrinology, Diabetes, and Obesity
|February 14, 2012
Summary
Automated insulin delivery systems using glucose sensors and insulin pumps show promise for type 1 diabetes management. Further outpatient trials are needed to confirm safety and efficacy of these advanced closed-loop systems.
Area of Science:
- Biomedical Engineering
- Endocrinology
- Diabetes Technology
Background:
- Advancements in continuous glucose monitoring and insulin pump technology have paved the way for automated insulin delivery systems.
- Significant expansion in research centers and literature reports over the past two years highlights rapid progress in this field.
Purpose of the Study:
- To review and highlight advancements in automated systems for improved type 1 diabetes management.
- To provide an overview of the progress in developing partially or completely automated insulin delivery solutions.
Main Methods:
- Review of current literature on automated insulin delivery systems.
- Analysis of parallel development in various automated control approaches.
Main Results:
- Multiple strategies, including automated suspension for hypoglycemia and augmentation for hyperglycemia, are under development.
- Early studies demonstrate potential for reducing hypoglycemia and enhancing diabetes control in inpatient settings.
Conclusions:
- Current components (sensors, pumps, algorithms) show potential for closed-loop systems but are primarily limited to inpatient studies.
- Future research should prioritize controlled, short-term outpatient trials to assess safety and efficacy.
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