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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
Secreted klotho and chronic kidney disease
Ming Chang Hu1, Makoto Kuro-o, Orson W Moe
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Advances in Experimental Medicine and Biology
|March 8, 2012
Summary
Soluble Klotho (sKl) is a key factor in aging and kidney disease. Boosting Klotho levels shows promise for treating chronic kidney disease and its complications.
Area of Science:
- Endocrinology and Metabolism
- Nephrology
- Molecular Biology
Background:
- Soluble Klotho (sKl) is derived from alternative splicing or shedding of membrane Klotho.
- Unlike membrane Klotho, sKl acts as a hormone with roles in anti-aging, anti-oxidation, ion transport, and Wnt signaling.
- Klotho deficiency is an early biomarker and pathogenic factor in chronic kidney disease (CKD).
Purpose of the Study:
- To review the role of soluble Klotho in chronic kidney disease.
- To highlight Klotho's potential as a biomarker and therapeutic target for CKD.
Main Methods:
- Review of existing literature on Klotho's function and its role in CKD.
- Analysis of experimental models demonstrating Klotho's protective effects in kidney disease.
Main Results:
- Klotho deficiency is linked to CKD progression and complications like vascular calcification and cardiac hypertrophy.
- Experimental models show that sKl replacement or upregulation protects kidneys from injury, preserves function, and reduces fibrosis.
Conclusions:
- Soluble Klotho is a promising early biomarker for chronic kidney disease.
- Klotho represents a novel therapeutic strategy for managing CKD and its associated complications.
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