Related Experiment Video
Updated: May 24, 2026
10:14
Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
Published on: May 26, 2023
Age-related macular degeneration
Sam Khandhadia1, Jocelyn Cherry, Andrew John Lotery
1Department of Clinical Neurosciences, Southampton General Hospital, Southampton, UK.
Advances in Experimental Medicine and Biology
|March 14, 2012
Summary
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness. Understanding AMD
Area of Science:
- Ophthalmology
- Neuroscience
Background:
- Age-related macular degeneration (AMD) is the primary cause of irreversible vision loss in developed nations.
- AMD significantly contributes to patient morbidity despite recent therapeutic advancements.
Purpose of the Study:
- To provide a foundational understanding of retinal structure and AMD characteristics for non-specialists.
- To outline current AMD management strategies, pathogenesis theories, and ongoing clinical trials.
- To highlight parallels between AMD and other neurodegenerative conditions.
Main Methods:
- Review of retinal structure and AMD pathology.
- Discussion of clinical features and current management.
- Exploration of AMD pathogenesis theories and neurodegenerative disease similarities.
- Survey of ongoing clinical trials for future treatments.
Main Results:
- AMD presents characteristic retinal changes and clinical features.
- Multiple risk factors contribute to AMD pathogenesis.
- Similarities exist between AMD and other neurodegenerative diseases.
- Numerous clinical trials are investigating novel AMD treatments.
Conclusions:
- A comprehensive, multi-faceted approach is essential for preventing AMD-related blindness.
- Further research into AMD pathogenesis and treatment is crucial.
- Early detection and intervention strategies are key to managing AMD.
More Related Videos
Related Concept Videos
01:27Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
01:22Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
01:22Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
01:22iPS Cell Differentiation
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.