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Related Concept Videos

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Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Related Experiment Video

Updated: May 23, 2026

Identification and Characterization of Metastatic Factors by Gene Transfer into the Novel RIP-Tag; RIP-tva Murine Model
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Understanding RAMPs through genetically engineered mouse models.

Mahita Kadmiel1, Kimberly L Fritz-Six, Kathleen M Caron

  • 1Department of Cell and Molecular Physiology, The University of North Carolina, Chapel Hill, NC, USA.

Advances in Experimental Medicine and Biology
|March 22, 2012
PubMed
Summary
This summary is machine-generated.

Receptor Activity Modifying Proteins (RAMPs) play crucial roles in development and adulthood, influencing G protein-coupled receptor signaling. Genetically engineered mouse models reveal their physiological significance and therapeutic potential.

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Area of Science:

  • Molecular Biology
  • Physiology
  • Genetics

Background:

  • Receptor Activity Modifying Proteins (RAMPs) are key modulators of G protein-coupled receptor (GPCR) signaling.
  • RAMPs influence receptor trafficking, ligand binding, and signal desensitization.
  • RAMPs interact with various GPCRs beyond the calcitonin receptor-like receptor (CLR).

Purpose of the Study:

  • To investigate the physiological significance of RAMPs in normal and disease states.
  • To provide an overview of findings from gene-targeted knockout and transgenic mouse models.
  • To highlight the utility of comparative phenotyping and conditional deletion strategies.

Main Methods:

  • Generation and characterization of gene-targeted RAMP knockout mouse models.
  • Development and analysis of transgenic RAMP over-expression mouse models.
  • Comparative phenotyping and conditional deletion strategies in mouse models.

Main Results:

  • RAMP knockout and over-expression models have demonstrated critical roles for RAMPs in embryonic development and adulthood.
  • These models provide insights into RAMP functions in various physiological processes.
  • Comparative phenotyping and conditional deletion enhance the understanding of RAMP functions.

Conclusions:

  • RAMPs are essential for normal physiological functions throughout development and adulthood.
  • Genetically engineered mouse models are invaluable tools for studying RAMPs.
  • RAMP-based therapies hold promise for treating human diseases.