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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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[The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study]

Ibrahim Halil Altıparmak1, Zekeriya Kaya, Hatice Sezen

  • 1Şanlıurfa Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Şanlıurfa, Turkey. ihaltiparmak@gmail.com

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|April 3, 2012
PubMed

Insights

Decreased serum paraoxonase-1 enzyme activity (SPA) and high-density lipoprotein-cholesterol (HDLC) levels are linked to coronary artery ectasia (CAE) development, similar to coronary artery disease (CAD). This suggests SPA and HDLC may play roles in CAE pathogenesis.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Biomarkers

Context:

  • Coronary artery ectasia (CAE) involves abnormal coronary artery dilatations.
  • Paraoxonase-1 (PON-1) is an antioxidant enzyme associated with high-density lipoprotein-cholesterol (HDLC).
  • PON-1's role in CAE pathogenesis is not fully understood.

Purpose:

  • To investigate serum paraoxonase-1 enzyme activity (SPA) in patients with CAE.
  • To compare SPA levels in CAE patients with those having coronary artery disease (CAD) and normal coronary arteries (NCA).

Summary:

  • This cross-sectional study compared SPA and HDLC levels in 44 CAE patients, 40 with critical CAD, 40 with minimal CAD, and 40 with NCA.
  • No significant differences in age, sex, diabetes, hypertension, or smoking were observed between groups.
  • Lowest HDLC was found in CAD patients, while NCA patients had the highest. CAE and CAD groups showed similar HDLC levels.
  • Lowest SPA was observed in CAD patients, with NCA patients showing the highest. CAE and CAD groups exhibited similar SPA levels.

Impact:

  • Findings suggest that decreased SPA and HDLC levels are associated with CAE development, mirroring associations seen in CAD.
  • These results indicate potential roles for SPA and HDLC in the pathophysiology of CAE.
  • This research highlights potential biomarkers for CAE risk stratification and understanding disease mechanisms.
Abstract

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