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Exercise Test for Evaluation of the Functional Efficacy of the Pig Cardiovascular System

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[Are genetic tests useful for cardiovascular prevention?].

Murielle Bochud¹, Florence Fellmann, Idris Guessous

¹Unité de prévention communautaire, Institut de médecine sociale et préventive, CHUV, 1011 Lausanne. Murielle.Bochud@chuv.ch

Revue Medicale Suisse

|April 5, 2012

Summary

Genetic testing shows promise for rare inherited heart conditions but is not yet clinically useful for common complex cardiovascular diseases. Current guidelines do not recommend genetic testing for cardiovascular prevention strategies.

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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Area of Science:

Genetics and Genomics
Cardiovascular Medicine
Personalized Medicine

Context:

Advances in genetic research offer new insights into cardiovascular disease (CVD) pathophysiology.
Genetic testing has high predictive value for rare monogenic cardiovascular diseases.
Common polygenic cardiovascular diseases (e.g., myocardial infarction, stroke, type 2 diabetes) present different challenges.

Purpose:

To evaluate the clinical utility of genetic testing in cardiovascular disease.
To assess the applicability of genetic insights for personalized cardiovascular medicine.
To determine the current recommendations for genetic testing in cardiovascular prevention.

Summary:

Genome-wide association studies (GWAS) provide valuable research data but lack clinical utility for common polygenic CVDs.
Genetic testing is not currently recommended for guiding cardiovascular prevention in clinical or public health settings.
The predictive value of genetic tests is high for monogenic diseases but limited for complex polygenic conditions.

Impact:

Highlights the gap between genetic research findings and clinical application in cardiovascular prevention.
Informs healthcare providers and policymakers about the current limitations of genetic testing for common cardiovascular diseases.
Sets expectations for the future role of genetics in personalized cardiovascular medicine, emphasizing the need for further validation.