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Using Extraordinary Optical Transmission to Quantify Cardiac Biomarkers in Human Serum
Published on: December 13, 2017
Methods to array photonic crystal microcavities for high throughput high sensitivity biosensing on a silicon-chip
Yi Zou1, Swapnajit Chakravarty, Wei-Cheng Lai
1Department of Electrical and Computer Engineering, University of Texas Austin, TX 78712, USA. raychen@uts.cc.utexas.edu
Lab on a Chip
|April 24, 2012
Summary
We developed a chip-integrated photonic crystal sensor microarray for sensitive, simultaneous detection of multiple analytes. This biosensor achieves high sensitivity, detecting down to 98 attograms, enabling multiplexed antibody detection.
Area of Science:
- Photonics
- Nanotechnology
- Biomedical Engineering
Background:
- Photonic crystal microcavities offer high sensitivity for biosensing.
- Multiplexed detection is crucial for efficient biological analysis.
Purpose of the Study:
- To demonstrate a scalable method for creating chip-integrated photonic crystal sensor microarrays.
- To achieve simultaneous detection of multiple analytes with high sensitivity.
Main Methods:
- Utilized multi-mode interference (MMI) power splitters and photonic crystal waveguides.
- Employed L13 photonic crystal microcavities with high Q values (~9300) in phosphate-buffered saline (PBS).
Main Results:
- Achieved high sensitivity, experimentally demonstrated to ~98 attograms.
- Successfully detected two different probe antibodies simultaneously with a control sample in a single experiment.
Conclusions:
- The developed method enables large-scale fabrication of photonic crystal sensor microarrays.
- The sensor platform demonstrates potential for sensitive and multiplexed biomolecular detection.
