Related Experiment Video
Updated: May 22, 2026
08:45
Generation of Functional Endodermal Hepatic Organoids
Published on: May 2, 2025
Endo-hepatology: a new paradigm
Kenneth J Chang1, Jason B Samarasena, Takuji Iwashita
1Division of Gastroenterology and Hepatology, H.H. Chao Comprehensive Digestive Disease Center, University of California, Irvine, 101 The City Drive, Orange, CA 92868, USA. kchang@uci.edu
Gastrointestinal Endoscopy Clinics of North America
|May 29, 2012
Summary
Hepatology has advanced with new viral hepatitis treatments, increasing the need for liver function assessment. The integration of endoscopic procedures into hepatology practice is proposed as endo-hepatology.
Area of Science:
- Hepatology and Gastroenterology
- Minimally Invasive Procedures
Background:
- Recent advancements in viral hepatitis treatment necessitate improved liver function assessment and histology evaluation.
- There is a growing number of endoscopic procedures relevant to patients with liver disease.
- Current practices often separate hepatology and endoscopic procedures, creating a gap in integrated patient care.
Purpose of the Study:
- To introduce and define the concept of endo-hepatology.
- To highlight the benefits of integrating endoscopic procedures within hepatology practice.
- To advocate for a unified approach to liver disease and portal hypertension management.
Main Methods:
- Conceptual framework development.
- Literature review of current hepatology and endoscopy practices.
- Analysis of the overlap between liver disease management and endoscopic interventions.
Main Results:
- Identification of a significant overlap between hepatology and gastrointestinal endoscopy.
- The proposed field of endo-hepatology offers a framework for integrating these disciplines.
- This integration can streamline the assessment and treatment of liver disease and portal hypertension.
Conclusions:
- Endo-hepatology represents a crucial integration of endoscopic procedures within hepatology.
- This unified approach can enhance the comprehensive care of patients with liver disease.
- Specialists in liver/gastrointestinal diseases can benefit from adopting endo-hepatology principles.
More Related Videos
Related Concept Videos
01:24Cirrhosis II: Pathophysiology
Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
01:22Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
01:29Hepatic Encephalopathy
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic shunting—including...
01:21Hepatic Portal System
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...
01:28Viral Hepatitis I: Introduction
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
01:21Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...