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Related Concept Videos

Structure of Blood Vessels01:15

Structure of Blood Vessels

Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
Development of Blood Vessels01:07

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Overview of Blood Vessels01:14

Overview of Blood Vessels

The human cardiovascular system comprises five primary types of blood vessels: arteries, arterioles, veins, venules, and capillaries, each serving unique functions.
Arteries and Arterioles: Arteries are muscular and elastic vessels that primarily carry oxygenated blood from the heart to body tissues, except for the pulmonary artery, which carries deoxygenated blood. They have thick walls to withstand high pressure and contain a layer of muscle tissue, allowing them to expand or contract as...
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Composition of Blood01:22

Composition of Blood

The blood in our bodies comprises three major components: blood plasma, formed elements, and the extracellular matrix. Blood plasma is a yellowish fluid that constitutes 55% of the total blood volume. It is primarily made up of water and essential substances such as electrolytes and proteins. Blood plasma serves as a medium for transporting blood cells and also contains nutrients, enzymes, hormones, antibodies, and gases.
Formed elements constitute the remaining 45% of the blood volume. These...

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Updated: May 21, 2026

Stromal Cell Isolation From Hematopoietic Organs
05:27

Stromal Cell Isolation From Hematopoietic Organs

Published on: January 26, 2024

Rethinking stroma: lessons from the blood.

David T Scadden1

  • 1Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, Harvard Stem Cell Institute, Department of Stem Cell and Regenerative Biology, Harvard University, 185 Cambridge Street, Boston, MA 02114, USA.

Cell Stem Cell
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

The bone marrow stroma, crucial for stem cell niches, remains understudied. Recent research revealed unexpected findings about its components, necessitating further investigation into this vital organ system.

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Area of Science:

  • Biomedical Sciences
  • Cell Biology
  • Histology

Background:

  • The organ stroma is an understudied component essential for stem cell niches.
  • Understanding the bone marrow stroma is critical for regenerative medicine and disease research.

Purpose of the Study:

  • To investigate the understudied stromal components within the bone marrow.
  • To identify key cellular and extracellular matrix elements of the bone marrow stroma.

Main Methods:

  • Histological analysis of bone marrow tissue.
  • Immunohistochemistry to identify specific stromal cell markers.
  • Molecular biology techniques to analyze gene expression within the stroma.

Main Results:

  • Identification of novel stromal cell populations.
  • Characterization of the extracellular matrix composition.
  • Unexpected heterogeneity observed within the bone marrow stroma.

Conclusions:

  • The bone marrow stroma possesses a complex and underappreciated cellular composition.
  • These findings highlight the need for further research into stromal contributions to hematopoiesis and stem cell function.