Osteoblast response on Ti- and Zr-based bulk metallic glass surfaces after sand blasting modification

The present study aimed to evaluate the osteoblast response on Ti- and Zr-based BMG surfaces sand blasted with different grit corundums for implant application, with mechanically polished disks before sand blasting as control groups. The surface properties were characterized by scanning electron microscopy (SEM), contact angle, and roughness measurements. Further evaluation of the surface bioactivity was conducted by MG63 cell attachment, proliferation, morphology, and alkaline phosphatase (ALP) activity on the sample surfaces. It was found that corundum sand blasting surfaces significantly increased the surface wettability and MG63 cell attachment, cell proliferation, and ALP activity in comparison with the control group surfaces. Besides, the sample surface treated by large grit corundum is more favorable for cell attachment, proliferation, and differentiation than samples treated by small grit corundum, indicating that it might be effective for improving implant osseointegration in vivo.