Related Experiment Video
Updated: May 18, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Endogenous regulators of NO bioavailability in rats with acute renal failure
R A Sukhovershin1, M A Gilinsky
1Laboratory for the Regulation of Adaptation Processes, Institute of Physiology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. suhovershin@physiol.ru
Abstract:
We studied the impact of acute glycerol-induced renal failure on blood levels and daily urinary excretion of arginine, monomethylarginine, and asymmetric and symmetric dimethylarginine. Acute renal failure was accompanied by enhanced daily excretion of asymmetric and symmetric dimethylarginine, increased plasma level of symmetric dimethylarginine, and decreased plasma level of arginine. Reabsorption of arginine and its methylated analogues decreased, thus compensating for reduced glomerular filtration rate. These data attest to increased production of dimethylarginines during acute renal failure. These changes can decrease NO bioavailability.
Related Concept Videos
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Drug Dosing in Renal Diseases: Dose Adjustments Based on Drug Clearance and Elimination Rate Constant
Bioavailability: Influencing Factors
Renal Drug Excretion: Tubular Secretion
Acute Kidney Injury II: Pathophysiology

