Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cellular Injury IV: Necrosis01:16

Cellular Injury IV: Necrosis

Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
Necrosis01:16

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac emergencies: infective endocarditis, pericarditis, and myocarditis.

The Medical clinics of North America·2012
Same author

Intra-abdominal and pelvic emergencies.

The Medical clinics of North America·2012
Same author

Medical Clinics of North America. Interventions in infectious disease emergencies. Preface.

The Medical clinics of North America·2012
Same author

Immunotherapy in clinical medicine: historical perspective and current status.

The Medical clinics of North America·2012
Same author

Immunotherapies in infectious diseases.

The Medical clinics of North America·2012
Same author

Immunotherapy in clinical medicine.

The Medical clinics of North America·2012

Related Experiment Videos

Necrotizing soft-tissue infections.

Praveen K Mullangi1, Nancy Misri Khardori

  • 1Division of Infectious Diseases, Springfield Clinic, Springfield, IL 62701, USA. pmullangi@springfieldclinic.com

The Medical Clinics of North America
|October 30, 2012
PubMed
Summary

Necrotizing soft tissue infections (NSTIs) are medical emergencies that require prompt treatment. Early recognition and aggressive surgical debridement, supportive care, and antibiotics are crucial for improving patient outcomes.

Area of Science:

  • Emergency Medicine
  • Surgical Critical Care
  • Infectious Diseases

Background:

  • Necrotizing soft tissue infections (NSTIs) represent a severe surgical and medical emergency.
  • Initial clinical presentation of NSTIs can be deceptive, potentially delaying diagnosis and treatment.
  • Delayed surgical debridement in NSTI cases is consistently linked to increased patient mortality.

Purpose of the Study:

  • To emphasize the critical importance of early recognition and prompt management of NSTIs.
  • To highlight the key components of effective therapy for NSTIs.
  • To underscore the impact of timely intervention on patient morbidity and mortality.

Main Methods:

  • Review of clinical presentations and outcomes associated with NSTIs.
  • Analysis of the relationship between the timing of surgical debridement and mortality rates.

Related Experiment Videos

  • Evaluation of the effectiveness of combined therapeutic strategies.

    • Main Results:

    • A high index of suspicion is essential for the early diagnosis of NSTIs.
    • Prompt initiation of therapy, including surgical debridement, is vital.
    • Aggressive supportive care and appropriate antibiotic therapy are integral to treatment.

    Conclusions:

    • Early diagnosis and prompt, aggressive treatment significantly reduce morbidity and mortality in NSTIs.
    • Multifaceted management involving surgical intervention, supportive care, and antibiotics is key.
    • Timely and decisive action is paramount in managing this life-threatening condition.