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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
Published on: July 24, 2016
Pediatric intracranial infections
Hemant Parmar1, Mohannad Ibrahim
1Division of Neuroradiology, Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109-0302, USA. hparmar@umich.edu
Insights
Pediatric central nervous system (CNS) infections require prompt diagnosis to prevent brain damage. This review covers congenital and bacterial CNS infections in children, noting distinct causes but similar imaging to adults.
Area of Science:
- Pediatric neurology
- Neuroinfectious diseases
- Medical imaging
Background:
- Central nervous system (CNS) infections in children are a critical concern, necessitating early detection to prevent lasting neurological deficits, particularly in neonates.
- Causal agents and clinical manifestations of pediatric CNS infections differ significantly from adult presentations.
- Despite differing etiologies, imaging characteristics of CNS infections in children often resemble those seen in adults.
Purpose of the Study:
- To provide a comprehensive review of common pediatric central nervous system infections.
- To highlight the importance of early recognition and diagnosis in managing pediatric neuroinfections.
- To discuss congenital and bacterial infections affecting the pediatric CNS.
Main Methods:
- Review of existing literature on pediatric central nervous system infections.
- Discussion of congenital (in utero) infections.
- Examination of bacterial infections involving the meninges and brain parenchyma.
Main Results:
- Pediatric CNS infections present unique challenges due to differing causative factors and clinical signs compared to adults.
- Imaging findings in pediatric CNS infections share similarities with adult presentations, aiding in diagnosis.
- Congenital infections and bacterial meningitis/encephalitis are significant concerns in pediatric populations.
Conclusions:
- Early identification of pediatric CNS infections is crucial for mitigating long-term neurological sequelae.
- Understanding the specific epidemiology and clinical features of pediatric neuroinfections is essential for effective management.
- Imaging plays a vital role in diagnosing CNS infections across pediatric age groups.
Abstract:
Infection of the central nervous system (CNS) in children is an important entity and early recognition is paramount to avoid long-term brain injury, especially in very young patients. The causal factors are different in children compared with adults and so are the clinical presentations. However, imaging features of CNS infection show similar features to those of adults. This article reviews some of the common types of pediatric infections, starting with the congenital (or in utero) infections followed by bacterial infections of the meninges and brain parenchyma.
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