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Updated: May 17, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

[Th17 cells and skin diseases].

Yoshiki Tokura¹

¹Department of Dermatology, Hamamatsu University School of Medicine.

Nihon Rinsho Men'Eki Gakkai Kaishi = Japanese Journal of Clinical Immunology

|November 6, 2012

Summary

T helper 17 (Th17) cells are vital for host defense but can drive autoimmune diseases. Increased Th17 cells are linked to skin conditions like psoriasis, atopic dermatitis, and drug eruptions.

Area of Science:

Immunology
Dermatology
Cellular Biology

Background:

T helper 17 (Th17) cells are critical for immune responses and host defense.
Dysregulation of Th17 cell activity is implicated in various autoimmune and inflammatory conditions.
Th17 cells, co-expressing IL-22, interact with keratinocytes via IL-22 receptors, influencing skin immunity.

Purpose of the Study:

To explore the role of Th17 cells in the pathogenesis of skin disorders.
To investigate the association between Th17 cell levels and specific dermatological conditions.
To understand the contribution of Th17 cells to inflammatory skin diseases.

Main Methods:

Analysis of Th17 cell populations in patients with skin diseases.
Correlation studies assessing Th17 cell percentages with disease severity.

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Review of existing literature on Th17 cell involvement in skin inflammation.

Main Results:

Th17 cells are increasingly recognized for their role in the pathogenesis of skin disorders, notably psoriasis.
Elevated percentages of Th17 cells are observed in the peripheral blood of patients with atopic dermatitis (AD).
Increased circulating Th17 cells are also associated with the severity of AD and are found in patients with drug eruptions.

Conclusions:

Th17 cells play a significant role in the immune response within the skin.
Aberrant Th17 cell activity contributes to the development and progression of inflammatory skin diseases.
Monitoring Th17 cell levels may offer insights into disease activity and severity in conditions like AD and psoriasis.