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Updated: May 15, 2026
09:51
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
Published on: July 16, 2017
DB Dehydrogenase: an online integrated structural database on enzyme dehydrogenase
Suman Kumar Nandy1, Rajabrata Bhuyan, Alpana Seal
1Department of Biochemistry & Biophysics, University of Kalyani, Kalyani, Dt. - Nadia, West Bengal, India.
Bioinformation
|January 1, 2013
Summary
Dehydrogenase enzymes are crucial for metabolism. The DB Dehydrogenase database integrates sequence, structure, and function data for these enzymes, aiding research into diseases like cancer and Alzheimer's.
Area of Science:
- Biochemistry
- Structural Biology
- Bioinformatics
Background:
- Dehydrogenase enzymes are vital for metabolic processes.
- Deficiencies in dehydrogenases are linked to diseases such as cancer, diabetes, and Alzheimer's.
- A gap exists between understanding dehydrogenase structure and function due to data volume.
Purpose of the Study:
- To bridge the gap between dehydrogenase structure and function.
- To create a centralized, web-based resource for dehydrogenase data.
- To facilitate research on dehydrogenase-related diseases.
Main Methods:
- Developed a web-based structural database named DB Dehydrogenase.
- Extracted and integrated data from various online resources.
- Implemented using a MySQL relational database with CGI Perl interfaces.
Main Results:
- The database covers approximately 150 enzyme classes and 1200 entries from 160 organisms.
- Provides integrated sequence, structure, and function data for known dehydrogenases.
- Offers flexible search options and cross-referencing capabilities.
Conclusions:
- DB Dehydrogenase consolidates essential dehydrogenase information in one location.
- The database serves as a valuable tool for researchers in the field.
- Facilitates further investigation into dehydrogenase roles and associated diseases.
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