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In Vivo Multimodal Imaging and Analysis of Mouse Laser-Induced Choroidal Neovascularization Model
Published on: January 21, 2018
Choroidal mapping; a novel approach for evaluating choroidal thickness and volume
Jila Noori1, Mohammad Riazi Esfahani, Fedra Hajizadeh
1Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences.
Journal of Ophthalmic & Vision Research
|January 1, 2013
Summary
Enhanced depth imaging optical coherence tomography (EDI-OCT) allows non-invasive imaging of the choroid. Choroidal mapping is introduced as a novel method for detailed topographic and volumetric analysis in various conditions.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- The choroid, crucial for retinal health, is affected by various disorders like polypoidal choroidal vasculopathy and tumors.
- Non-invasive imaging of the choroid has been limited, hindering diagnosis and monitoring of related conditions.
- Standard imaging techniques often struggle to provide detailed choroidal structural information.
Purpose of the Study:
- To review the utility of enhanced depth imaging optical coherence tomography (EDI-OCT) for choroidal imaging.
- To introduce choroidal mapping as a novel technique for assessing choroidal topography and volume.
- To evaluate the application of these methods in both normal and diseased states of the choroid.
Main Methods:
- Utilized enhanced depth imaging optical coherence tomography (EDI-OCT) with standard spectral-domain OCT machines.
- Developed and applied choroidal mapping for topographic and volumetric analysis.
- Examined choroidal structures in vivo for both healthy subjects and patients with specific conditions.
Main Results:
- EDI-OCT provides in vivo cross-sectional imaging of the choroid, comparable to retinal imaging.
- Choroidal mapping enables accurate measurement of choroidal topographic and volumetric parameters.
- The technique is applicable for assessing choroidal changes in various retinal disorders and primary choroidal diseases.
Conclusions:
- EDI-OCT is a valuable non-invasive tool for choroidal visualization.
- Choroidal mapping represents a significant advancement for quantitative choroidal analysis.
- These imaging advancements aid in understanding and managing choroidal pathologies.
