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Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: May 14, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

The E2F1-miRNA cancer progression network.

Susanne Knoll1, Stephan Emmrich, Brigitte M Pützer

  • 1Department of Vectorology and Experimental Gene Therapy, Rostock University Medical Center, Rostock, Germany.

Advances in Experimental Medicine and Biology
|February 5, 2013
PubMed
Summary
This summary is machine-generated.

The transcription factor E2F1 has dual roles in cancer, suppressing tumors or promoting progression. Its interaction with microRNAs (miRNAs) influences E2F1

Related Experiment Videos

Last Updated: May 14, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • The transcription factor E2F1 functions as both a tumor suppressor and an oncogene.
  • E2F1 activation mediates apoptosis under cellular stress as an anti-tumorigenic mechanism.
  • In aggressive, chemoresistant cancers (melanoma, prostate, bladder), E2F1 promotes cancer progression.

Purpose of the Study:

  • To investigate the mechanisms underlying E2F1's role in cancer invasiveness and metastasis.
  • To explore the feedback loops and regulatory network between E2F1 and microRNAs (miRNAs).

Main Methods:

  • Review and summarization of existing research on E2F1 and miRNA interactions.
  • Analysis of regulatory feedback loops influencing E2F1's proapoptotic versus prosurvival functions.

Main Results:

  • E2F1's role shifts from tumor suppression to oncogenesis in advanced, chemoresistant cancers.
  • Epigenetic inactivation of tumor suppressor genes contributes to E2F1-mediated aggressiveness.
  • Feedback loops exist where E2F1 activates miRNAs, which in turn regulate E2F1 or its target genes.

Conclusions:

  • The complex interplay between E2F1 and miRNAs significantly impacts the balance of its functions.
  • Understanding these miRNA-E2F1 interactions is crucial for deciphering E2F1's role in cancer progression and chemoresistance.