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Updated: May 14, 2026

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
[Fat distribution and its relationship with genetic polymorphism in patients with nonalcoholic liver disease]
1GI L.T. Malaya Therapy Institute of the NAMS Ukraine, Kharkov, Ukraine.
Abstract:
The article presents the results of research which demonstrated that the features of fat distribution in patients with non-alcoholic fatty liver disease (NAFLD), which depended on the sex and the activity of alanine transaminase. It is shown that carriers G allele rs6666089ADIPOR1 had significantly higher levels of visceral, subcutaneous adipose tissue and their relation and% liver fat in the compared with carriers A allele. The findings suggest that the development of more severe hepatic steatosis in carriers of GG genotype of rs6666089 ADIPOR1, confirming participation in the formation of ectopic fat NAFLD.
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