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07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Lipoprotein(a) in cardiovascular diseases
Michele Malaguarnera1, Marco Vacante, Cristina Russo
1International Ph. D. Program in Neuropharmacology, University of Catania, 95123 Catania, Italy. m.malaguarnera@email.it
Biomed Research International
|March 14, 2013
Summary
High lipoprotein(a) (Lp(a)) levels are a significant risk factor for cardiovascular diseases, including heart attack and stroke. Lp(a)-lowering therapies show promise for reducing cardiovascular events in high-risk individuals.
Area of Science:
- Cardiology
- Biochemistry
- Molecular Biology
Background:
- Lipoprotein(a) (Lp(a)) is an LDL-like particle implicated in cardiovascular disease risk.
- Lp(a) comprises apolipoprotein B-100 (apo(B-100)) linked to apo(a).
- Elevated Lp(a) is an independent predictor of coronary artery disease and myocardial infarction.
Purpose of the Study:
- To review the role of Lp(a) as a risk factor for various cardiovascular conditions.
- To explore the mechanisms by which Lp(a) contributes to atherosclerosis.
- To assess the potential of Lp(a)-lowering therapies.
Main Methods:
- Literature review of observational studies and clinical findings.
- Analysis of Lp(a)'s molecular interactions and biological effects.
- Evaluation of therapeutic strategies targeting Lp(a).
Main Results:
- Lp(a) promotes arterial lesion growth by affecting smooth muscle cells and inhibiting TGF activation.
- Lp(a) impairs fibrinolysis by inhibiting plasminogen binding and decreasing tissue-type plasminogen activator activity.
- Lp(a) is associated with restenosis, graft atherosclerosis, and potentially ischemic stroke.
Conclusions:
- Elevated Lp(a) is a crucial risk marker for coronary artery disease, myocardial infarction, and other cardiovascular events.
- Lp(a) acts as a proinflammatory mediator in atherosclerotic plaque formation.
- Therapeutic strategies, including apheresis, to lower Lp(a) may reduce major coronary events.
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