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Updated: May 13, 2026

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

Published on: May 2, 2025

Epigenetics-Based Therapeutics for Neurodegenerative Disorders.

Zihui Xu¹, He Li, Peng Jin

¹Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA ; Division of Histology and Embryology, Department of Anatomy, Tongji Medical College, Huazhong University of Science and Technology, P. R. China.

Current Translational Geriatrics and Experimental Gerontology Reports

|March 26, 2013

Summary

Epigenetic modifications like DNA methylation and histone changes are key in neurodegenerative diseases. New epigenetics-based drugs show promise for treating conditions such as Alzheimer

Keywords:

Alzheimer’s disease Amyotrophic lateral sclerosis DNA demethylation DNA methylation DNMT inhibitors HDAC inhibitors Histone acetylation Huntington’s disease Neurodegeneration Parkinson’s disease Therapeutics

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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

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Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

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Published on: March 29, 2019

Area of Science:

Neuroscience
Genetics
Pharmacology

Background:

Epigenetic regulation, including DNA methylation and histone modification, influences gene expression.
Aberrant epigenetic changes are linked to the progression of neurodegenerative disorders.

Purpose of the Study:

To review recent studies on the role of epigenetic modifications in neurodegeneration.
To explore the therapeutic potential of epigenetics-based treatments for neurodegenerative diseases.

Main Methods:

Literature review of studies on DNA methylation/demethylation and histone acetylation/deacetylation in neurodegeneration.
Analysis of emerging epigenetics-based therapeutic strategies.

Main Results:

Epigenetic modifications are significantly implicated in the pathogenesis of neurodegenerative conditions.
Several epigenetics-based drugs are under development for Alzheimer's, Parkinson's, and Huntington's diseases.

Conclusions:

Epigenetic mechanisms are crucial in neurodegenerative disease progression.
Epigenetics-based therapeutics offer a promising avenue for treating neurodegenerative disorders.