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Updated: May 10, 2026

Preparation of Mica Supported Lipid Bilayers for High Resolution Optical Microscopy Imaging
Published on: June 7, 2014
Optical visualization of ultrathin mica flakes on semitransparent gold substrates
Aurora Dols-Perez1, Xavier Sisquella, Laura Fumagalli
1Nanobioelec Group, Institute for BioEngineering of Catalonia (IBEC), c/Baldiri i Reixac 15-21, Barcelona 08028, Spain. gabriel.gomila@ub.edu.
Abstract:
We show that optical visualization of ultrathin mica flakes on metallic substrates is viable using semitransparent gold as substrates. This enables to easily localize mica flakes and rapidly estimate their thickness directly on gold substrates by conventional optical reflection microscopy. We experimentally demonstrate it by comparing optical images with atomic force microscopy images of mica flakes on semitransparent gold. Present results open the possibility for simple and rapid characterization of thin mica flakes as well as other thin sheets directly on metallic substrates.

