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Updated: May 9, 2026
How to Build a Laser Speckle Contrast Imaging (LSCI) System to Monitor Blood Flow
Published on: November 11, 2010
Simultaneous imaging of cortical blood flow and haemoglobin concentration with LASCA and RGB reflectometry
André Steimers1, M Gramer2, M Takagaki2
1RheinAhr Campus Remagen, University of Applied Sciences Koblenz, Remagen, Germany. steimers@rheinahrcampus.de.
Abstract:
We demonstrate a system for the simultaneous imaging of cortical blood flow and haemoglobin oxygenation by laser speckle contrast analysis (LASCA) and RGB reflectometry. The sensitivity of the system was tested by observing changes of haemoglobin oxygenation and blood flow in rats in response to ischaemic stroke, hypercapnia, hyperoxia, hypoxia, cortical spreading depression and cortical activation following forepaw stimulation.
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