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Recombinant expression of backbone-cyclized polypeptides

Radhika Borra1, Julio A Camarero

  • 1Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA, 90033.

Biopolymers
|July 30, 2013
PubMed
Summary

Biochemical methods enable backbone-cyclized polypeptide production via recombinant DNA technology. This facilitates studies on protein stability and creates genetically encoded cyclic polypeptide libraries for discovering new biological activities.

Keywords:
cyclic peptideinteinprotein splicing

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