Related Experiment Video
Updated: May 8, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Periocular hidradenoma papilliferum.
Yasser H Al-Faky1, Abdul Rahman Al-Mosallam, Mohammed O Al-Sohaibani
1Ophthalmology Department, King Abdul Aziz University Hospital, King Saud University, P.O. Box 245, Riyadh 11411, Saudi Arabia.
Ectopic hidradenoma papilliferum, a rare skin tumor typically found in the anogenital area, can occur elsewhere. This case highlights an eyebrow lesion in a female patient, successfully treated with complete excision.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Hidradenoma papilliferum is a benign apocrine sweat gland neoplasm.
- It typically presents in the anogenital region of middle-aged white females post-puberty.
- Ectopic hidradenoma papilliferum, occurring outside this region, is exceptionally rare and can affect males.
Purpose of the Study:
- To report an exceedingly rare case of ectopic hidradenoma papilliferum.
- To describe the clinical presentation and management of a facial hidradenoma papilliferum.
- To contribute to the literature on rare adnexal neoplasms.
Main Methods:
- Case report of a female patient with a facial lesion.
- Complete surgical excision of the lesion.
- Follow-up to assess for recurrence.
Main Results:
- A female patient presented with a lesion near the left eyebrow, present since childhood.
- The lesion was located over the anterior medial superior orbital rim.
- Complete excision was performed, with no recurrence observed over four years of follow-up.
Conclusions:
- Ectopic hidradenoma papilliferum can occur in unusual locations, such as the face.
- Complete excision is an effective treatment for hidradenoma papilliferum.
- This case expands the known spectrum of locations for this rare benign neoplasm.
Related Concept Videos
Papillary Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Cirrhosis I: Introduction
Accessory Structures of the Skin: Sebaceous Glands
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
Appendicitis
Accessory Structures of the Skin: Sweat Glands
Sweat glands are classified as merocrine glands; that is, the secretions are excreted by exocytosis through a duct without affecting the cells of the gland. There...
Acne Infection