Putative drug targets in Rhizopus oryzae: in-silico insight

Opportunistic fungal infections, such as zygomycosis, often associated with excessive morbidity and mortality, are increasingly becoming a source of concern worldwide. In the reported investigation, genome analysis of a major opportunistic fungus Rhizopus oryzae was undertaken to identify gene or protein sequences that may serve as targets for therapeutic interventions. Using database of essential genes six proteins were identified. These proteins are implicated in metabolic/cellular pathways, which are more likely to be crucial for target organism's viability. Their utility as potential drug targets is discussed.