Multi-session radiosurgery of benign intracranial tumors

Multi-session stereotactic radiosurgery (SRS) enables a high dose per fraction to be delivered to the tumor bed with rapid dose falloff that allows for sparing of critical structures, resulting in less radiation-associated toxicity. In this article, the authors review the basic concepts and techniques of multi-session SRS, indications for this technique, outcomes from single-session and multi-session SRS using 3 commonly treated benign intracranial tumors (meningiomas, vestibular schwannomas, pituitary adenomas), and discuss why multi-session SRS is an attractive approach for the treatment of these tumors.