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Updated: May 5, 2026

Determination of the Relative Potency of an Anti-TNF Monoclonal Antibody mAb by Neutralizing TNF Using an In Vitro Bioanalytical Method
Published on: September 16, 2017
Lipid profile and anti-TNF-α use
Anti-tumor necrosis factor-alpha (TNF-α) therapy is linked to elevated triglyceride (TG) levels in patients with rheumatic diseases. This study found no significant changes in other lipid profiles, highlighting a specific impact on TGs.
Area of Science:
- Rheumatology
- Cardiovascular Medicine
- Pharmacology
Background:
- Anti-tumor necrosis factor-alpha (TNF-α) therapies are crucial for managing rheumatic diseases.
- Rheumatic diseases are associated with accelerated atherosclerosis, making lipid profile monitoring essential.
- Existing research on anti-TNF-α's impact on lipid profiles presents conflicting results.
Purpose of the Study:
- To investigate changes in lipid profiles (total cholesterol, HDLc, LDLc, ATI, TGs) in Southern Brazilian patients using anti-TNF-α.
- To assess the association between lipid profile alterations and duration of anti-TNF-α use, indications, patient gender, and drug type.
Main Methods:
- A cohort of 58 patients (42 rheumatoid arthritis, 16 spondyloarthritis) was studied.
- Lipid profiles were measured before and after a median of 16.0 months of anti-TNF-α treatment.
- Analysis included total cholesterol (TC), HDL cholesterol (HDLc), LDL cholesterol (LDLc), atherogenic index (ATI), and triglycerides (TGs).
Main Results:
- No significant changes were observed in TC, HDLc, LDLc, or ATI levels (P = NS).
- A statistically significant increase in triglyceride (TG) levels was detected (P = 0.03).
- The median increase in TG was 16 mg/dL and was not associated with gender, duration of use, indication, or anti-TNF-α type.
Conclusions:
- Anti-tumor necrosis factor-alpha (TNF-α) therapy is associated with increased triglyceride (TG) levels.
- This finding is important for understanding the link between rheumatic diseases, anti-TNF-α treatment, and cardiovascular risk.
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