Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

DNA Microarrays02:34

DNA Microarrays

16.8K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
16.8K
The DNA Helix01:16

The DNA Helix

129.4K
Overview
129.4K
The DNA Helix01:16

The DNA Helix

40.4K
40.4K
The DNA Helix01:07

The DNA Helix

19.9K
Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
19.9K
DNA-only Transposons02:57

DNA-only Transposons

16.0K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
16.0K
DNA as a Genetic Template02:05

DNA as a Genetic Template

7.5K
7.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A unimolecular GLP-1 and FGF21 dual agonist for treatment of metabolic dysfunction-associated steatohepatitis.

Communications medicine·2026
Same author

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Soaking Up Success: Sponge-Assisted Nanoparticle Transfection.

Research square·2026
Same author

Genetically Encoded Sterol-Modification of a Synthetic Intrinsically Disordered Protein Drives Its Self-Assembly Into Diverse Morphologies.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

All-PEG-Like Block Copolymers Self-Assemble into Stealth Nanocarriers for Drug Delivery.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Intrinsically Disordered Protein Coating for Oral Delivery of Peptide Drugs.

bioRxiv : the preprint server for biology·2025
Same journal

Fluorescent merocyanines: from fundamental properties to applications as molecular probes, in bioimaging and as emissive dye aggregates.

Chemical Society reviews·2026
Same journal

Direct impure water electrolysis at industrial scale.

Chemical Society reviews·2026
Same journal

Catalytic valorization of polyolefins: from catalysts and processes to reactors.

Chemical Society reviews·2026
Same journal

Designing stable π-radicals.

Chemical Society reviews·2026
Same journal

Antibacterial drug discovery: challenges and preclinical promises from synthetic small molecules.

Chemical Society reviews·2026
Same journal

Selective carbon-carbon bond cleavage involving alkene moieties.

Chemical Society reviews·2026
See all related articles

Related Experiment Video

Updated: May 4, 2026

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

21.7K

"Smart" DNA interfaces.

Vinalia Tjong1, Lei Tang, Stefan Zauscher

  • 1Department of Biomedical Engineering, Duke University, Box 90281, Durham, North Carolina 27708, USA. chilkoti@duke.edu.

Chemical Society Reviews
|December 20, 2013
PubMed
Summary
This summary is machine-generated.

Surface-grafted DNA acts as a directional building block for molecular recognition. This review explores its innovative uses in diagnostics, sequencing, and biosensing at surfaces and interfaces.

More Related Videos

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

3.9K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K

Related Experiment Videos

Last Updated: May 4, 2026

Designing a Bio-responsive Robot from DNA Origami
13:32

Designing a Bio-responsive Robot from DNA Origami

Published on: July 8, 2013

21.7K
DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

3.9K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

6.7K

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Molecular Biology

Background:

  • DNA's unique properties as a directional polyanion are leveraged.
  • Surface-grafting enables precise control over DNA orientation and functionality.
  • Molecular recognition capabilities of DNA are central to its applications.

Purpose of the Study:

  • To review the applications of surface-grafted DNA.
  • To highlight DNA's role as a molecular building block.
  • To showcase innovations in DNA surface functionalization.

Main Methods:

  • Review of existing literature on surface-grafted DNA.
  • Analysis of examples demonstrating DNA's use at surfaces and interfaces.
  • Focus on applications in diagnostics, sequencing, and biosensing.

Main Results:

  • Surface-grafted DNA serves as a versatile molecular building block.
  • DNA's directional polyanionic nature and molecular recognition are key.
  • Innovative applications span diagnostics, sequencing, and biosensing.

Conclusions:

  • Surface-grafted DNA offers significant potential in various technological fields.
  • Its unique properties enable advanced molecular diagnostics and biosensing.
  • Further research into DNA surface functionalization will drive innovation.