[Topical use of thrombin in prostatic surgery].

Area of Science:

• Urology
• Surgical Hemostasis

Background:

• Prostatic surgery often involves significant bleeding, necessitating effective hemostatic methods.
• Traditional hemostatic techniques can prolong operative time and blood loss.

Observation:

• A novel technique utilizing topical thrombin via a specialized catheter was employed for hemostasis in the prostatic fossa.
• Fifty patients were randomized to compare the thrombin method with conventional ligature hemostasis.

Findings:

• The thrombin method demonstrated statistically significant reductions in both operation time and operative blood loss compared to the ligature group.
• Postoperative hematuria duration was longer in the thrombin group, but this did not lead to clinical complications.
• Factors such as hypofibrinogenemia and suboptimal drug storage conditions can impact thrombin efficacy.

Implications:

• Topical thrombin offers a promising and effective hemostatic aid in prostatic surgery, improving surgical efficiency.
• Careful consideration of patient fibrinogen levels and drug storage is crucial for optimal outcomes with thrombin.
• This method presents a viable alternative for managing bleeding in transurethral prostatic procedures.