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Orbital and intraocular myofibroblastoma
Bryan R Costin1, Thomas P Plesec, Tal J Rubinstein
1Cole Eye Institute, Cleveland Clinic , Cleveland, Ohio , USA and.
Orbit (Amsterdam, Netherlands)
|January 14, 2014
Summary
A rare mammary-type myofibroblastoma was found in the orbit and globe of a patient. This benign tumor, characterized by specific cell markers, has not been previously reported in this location.
Area of Science:
- Ophthalmology
- Pathology
- Oncology
Background:
- Orbital and ocular tumors can present with varied clinical manifestations.
- Accurate diagnosis is crucial for appropriate management and prognosis.
Observation:
- A 66-year-old woman presented with a blind, painful, hypertensive, and proptotic left eye.
- Imaging revealed a well-circumscribed mass involving the left orbit and globe.
- Surgical removal via orbitotomy was performed, with the tumor excised in toto.
Findings:
- Histopathology and immunohistochemistry confirmed the mass as a mammary-type myofibroblastoma.
- The tumor consisted of fascicles of bland, uniform spindle cells positive for desmin and CD34.
- This represents the first reported case of orbital or ocular myofibroblastoma.
Implications:
- Mammary-type myofibroblastoma is a benign neoplasm with no known recurrence, malignant transformation, or metastatic potential.
- Recognition of its distinct clinical, histopathologic, and immunohistochemical features is vital.
- This knowledge can enhance diagnostic accuracy and guide treatment decisions for similar orbital masses.
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