[Fever of unknown origin in the elderly is a diagnostic challenge]
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Updated: Sep 15, 2026

Microbiological Rapid On-Site Evaluation for Pulmonary Infectious Diseases
Published on: March 1, 2024
Jolanta Zajworoniuk-Wlodarczyk1, Joanna Drozdowska, Hanne Pedersen
1Geriatrisk Afdeling, Nykøbing Falster Sygehus, Fjordvej 15, 4800 Nykøbing.
Abstract:
Elderly individuals often have different causes of fever of unknown origin compared to young persons. While infections dominate in the young, system diseases like temporal arteritis and polymyalgia rheumatica, malignancy and drug fever are common causes in the elderly. The symptoms may be blunted with lack of fever. Co-morbidities may complicate, dominate, and confuse the clinical impression. In the diagnostic work-up it is important to consider other co-morbidities and overall frailty. Patients should be informed and their wishes taken into account in the early phase of planning diagnostic work-up and treatment.
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