Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorder of Water Balance01:29

Disorder of Water Balance

2.1K
Water balance disorders are medical conditions that occur when there is a deviation from the body's water volume or osmolarity, disrupting normal homeostasis and leading todehydration, hypotonic hydration, hyperhydration, edema, or water intoxication.
Dehydration
Dehydration occurs when the body loses fluids (particularly water).
Causes:
The major causes of dehydration include excessive sweating, fever, vomiting, diarrhea, and diuresis.
Signs and Symptoms:
Symptoms primarily include intense...
2.1K
Regulation of Water Intake01:25

Regulation of Water Intake

2.2K
Osmolality refers to the number of solute particles per kilogram of solvent in a solution. Plasma osmolality specifically indicates the total number of solute particles per kilogram of water in blood plasma. This value reflects the body's hydration status and is tightly regulated through mechanisms controlling water intake and output. While water consumption is a conscious decision, the body has intrinsic regulatory systems to maintain fluid balance. Dehydration, a state of water deficit...
2.2K
Diabetes Insipidus I: Introduction01:29

Diabetes Insipidus I: Introduction

58
Definition Diabetes insipidus is a disorder marked by the production of large amounts of dilute urine because of impaired vasopressin production, release, or kidney response. The lack of effective vasopressin action limits water reabsorption in the renal collecting ducts, which leads to excessive urinary water loss and intense thirst.Clinical PresentationIndividuals with diabetes insipidus report persistent thirst and very high urine output. In severe cases, fluid intake can reach up to 20...
58
Diabetes Insipidus II: Pathophysiology01:22

Diabetes Insipidus II: Pathophysiology

29
Normally, water balance is maintained through three interconnected mechanisms: the hypothalamic thirst center, the synthesis and release of antidiuretic hormone (ADH, or vasopressin), and the kidneys' responsiveness to this hormone. ADH is synthesized in the hypothalamus, released from the posterior pituitary, and acts on the distal nephron, allowing water reabsorption and concentrated urine production.Diabetes Insipidus and Its TypesIn diabetes insipidus (DI), this regulatory system is...
29
Physiology of Urine Formation01:24

Physiology of Urine Formation

17.3K
Urine formation is an essential function of the human body. It plays a critical role in maintaining homeostasis by regulating the volume and composition of body fluids. The kidneys, the primary organs involved in this process, filter blood to remove waste products and excess substances, ultimately producing urine.
Glomerular Filtration
The first stage in urine formation is glomerular filtration. Each kidney contains approximately 1 million nephrons, the functional units of filtration, with a...
17.3K
Primary Motives: Hunger and Thirst01:25

Primary Motives: Hunger and Thirst

1.8K
Hunger and thirst are fundamental physiological drives crucial for maintaining homeostasis and ensuring the survival of both humans and animals. These drives are regulated through complex interactions between the brain, hormones, and sensory receptors.
Hunger arises when the brain detects changes in the body's nutrient levels, including glucose, lipids, amino acids, and hormones such as ghrelin and leptin. The hypothalamus plays a central role in hunger regulation. The lateral hypothalamus...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Under four, on the brink.

Journal of applied physiology (Bethesda, Md. : 1985)·2025
Same author

Utility of Body Weight, Urine Color, and Thirst Perception (WUT) in Determining Hydration in Young Adults.

Medicine and science in sports and exercise·2024
Same author

Exertional heat stress promotes the presence of bacterial DNA in plasma: A counterbalanced randomised controlled trial.

Journal of science and medicine in sport·2024
Same author

Iterative assessment of a sports rehydration beverage containing a novel amino acid formula on water uptake kinetics.

European journal of nutrition·2024
Same author

Effectiveness of an amino acid beverage formulation in diarrhea-predominant irritable bowel syndrome: A pragmatic real-world study.

World journal of gastrointestinal pharmacology and therapeutics·2024
Same author

Forecasting individual exercise sweat losses from forecast air temperature and energy expenditure.

Frontiers in sports and active living·2023
Same journal

Heart-Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes.

Comprehensive Physiology·2026
Same journal

The Adipose-Organ Communication Network in Clinical Obesity: From Adiposopathy to Systemic Metabolic Failure.

Comprehensive Physiology·2026
Same journal

Insight Into the Biological Link Between Novel Adiposity Indices and Incident Heart Failure.

Comprehensive Physiology·2026
Same journal

Domino Effect of the Kynurenine Pathway: Systemic Homeostasis, Metabolic Crosstalk, and Therapeutic Potential.

Comprehensive Physiology·2026
Same journal

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases.

Comprehensive Physiology·2026
Same journal

Sleep Disturbances and Male Reproductive Dysfunction: Pathophysiological Mechanisms Linking Obstructive Sleep Apnea and Sleep Deprivation.

Comprehensive Physiology·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

1.2K

Dehydration: physiology, assessment, and performance effects.

Samuel N Cheuvront1, Robert W Kenefick

  • 1Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts.

Comprehensive Physiology
|April 3, 2014
PubMed
Summary
This summary is machine-generated.

Dehydration assessment is crucial, distinguishing between intracellular and extracellular fluid loss. Performance impairment, especially in endurance exercise, is linked to significant dehydration, while strength and cognitive effects are less clear.

More Related Videos

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol
08:21

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol

Published on: June 8, 2017

11.0K
A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

3.8K

Related Experiment Videos

Last Updated: May 1, 2026

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test
10:21

Evaluation of Hydration Status by Bioelectrical Impedance Vector Analysis in Patients with Ischemic Heart Disease Undergoing Exercise Stress Test

Published on: September 22, 2023

1.2K
Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol
08:21

Non-invasive Assessments of Subjective and Objective Recovery Characteristics Following an Exhaustive Jump Protocol

Published on: June 8, 2017

11.0K
A Preclinical Model of Exertional Heat Stroke in Mice
08:22

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

3.8K

Area of Science:

  • Exercise Physiology
  • Sports Science
  • Human Performance

Background:

  • Dehydration significantly impacts physiological functions and athletic performance.
  • Accurate assessment of dehydration is critical for athletes and clinicians.
  • Existing literature often overlooks key physiological distinctions in dehydration.

Purpose of the Study:

  • To provide a comprehensive review of dehydration assessment methods.
  • To critically evaluate the existing literature on dehydration and performance.
  • To emphasize the physiological distinctions between intracellular and extracellular dehydration.

Main Methods:

  • Literature review and synthesis of dehydration and performance studies.
  • Analysis of physiological responses to dehydration (osmolality and volume changes).
  • Evaluation of diagnostic and biological variation in assessment methods.

Main Results:

  • A ≥ 2% dehydration threshold is associated with impaired endurance performance due to volume loss.
  • The distinction between intracellular and extracellular dehydration is vital for accurate assessment.
  • Evidence for dehydration impairing strength, power, or cognition is limited and context-dependent.

Conclusions:

  • Understanding the type of dehydration (intracellular vs. extracellular) is paramount for assessment.
  • Performance decrements are task-specific, with endurance exercise being most affected by dehydration.
  • Further research is needed to clarify the mechanisms and thresholds for dehydration impacting various physical and cognitive tasks.