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Related Experiment Video

Updated: May 1, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
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Multifunctional superparamagnetic fe3O4@SiO2 core/shell nanoparticles: design and application for cell imaging.

Xueling Zhao, Hongli Zhao, Huihui Yuan

    Journal of Biomedical Nanotechnology
    |April 18, 2014
    PubMed
    Summary

    Superparamagnetic iron oxide nanoparticles coated with silica, PEG, and folic acid show high biocompatibility and fluorescence. These targeted nanoparticles are efficiently internalized by cancer cells, offering potential for cancer imaging and therapy.

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    Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /T1Magnetic Resonance Imaging

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    Area of Science:

    • Nanotechnology
    • Biomaterials Science
    • Cancer Research

    Background:

    • Development of targeted nanomaterials for cancer therapy is crucial.
    • Superparamagnetic iron oxide nanoparticles (SPIONs) offer unique magnetic properties.
    • Biocompatible coatings and targeting ligands enhance nanoparticle efficacy and safety.

    Purpose of the Study:

    • To synthesize and characterize multifunctional Fe3O4@SiO2 core/shell nanoparticles.
    • To functionalize nanoparticles with poly(ethylene glycol) (PEG) and folic acid (FA) for targeted delivery.
    • To evaluate the cellular uptake and potential of these nanocomposites for cancer imaging and therapy.

    Main Methods:

    • w/o-microemulsion technique for nanoparticle synthesis.
    • Characterization using XRD, TEM, DLS, FT-IR, TGA, VSM, UV-vis, fluorescence spectroscopy, and CLSM.
    • In vitro evaluation of cellular uptake in HeLa and KB cancer cells.

    Main Results:

    • Monodisperse, sub-50-nm Fe3O4@SiO2 nanoparticles with luminescent silica shells were successfully synthesized.
    • Nanoparticles were effectively coated with PEG and FA, creating Fe3O4@SiO2-PEG-FA (SMNPs-FA) nanocomposites.
    • SMNPs-FA demonstrated superparamagnetic properties, high biocompatibility, and intense fluorescence.
    • Efficient uptake of SMNPs-FA by folate receptor-overexpressing HeLa and KB cancer cells was confirmed.
    • The nanomaterials effectively recognized and bound to target cancer cells.

    Conclusions:

    • The synthesized multifunctional SMNPs-FA are highly biocompatible, superparamagnetic, and fluorescent.
    • These targeted nanoparticles show efficient uptake by cancer cells overexpressing folate receptors.
    • SMNPs-FA represent a promising platform for targeted cancer cell imaging and future therapeutic applications.