Related Experiment Video
Updated: Apr 30, 2026
10:04
Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
17.1K
Tuberculosis reactivation risk in dermatology.
Leonardo Pescitelli1, Federica Ricceri, Francesca Prignano
1Address correspondence to Dr. Prignano, Division of Clinical, Preventive and Oncology Dermatology, Department of Surgery and Translational Medicine, Florence University, Ospedale Piero Palagi, V.le Michelangelo 41, 50125 Florence, Italy.
The Journal of Rheumatology. Supplement
|May 3, 2014
Summary
Psoriasis patients have a higher risk of tuberculosis (TB), with 50% showing latent infection. Biologic therapies, especially tumor necrosis factor (TNF) antagonists like etanercept, may influence TB reactivation risk.
Area of Science:
- Dermatology and Immunology
- Infectious Diseases
Background:
- Biologic therapies have transformed dermatological disease treatment, particularly psoriasis.
- These therapies target immune cells or cytokines, but may increase the risk of active tuberculosis (TB).
Purpose of the Study:
- To review safety data on TB reactivation risk associated with biologic agents used in dermatology.
- To assess the independent risk of TB in psoriasis patients and compare it with other conditions.
Main Methods:
- Review of published safety data on biologic agents for dermatological diseases.
- Analysis of TB prevalence and latent TB infection rates in psoriasis patients compared to inflammatory bowel disease patients.
Main Results:
- Psoriasis is an independent risk factor for TB, with a 18.0% prevalence in patients.
- Latent TB infection is significantly more common in psoriasis patients (50%) than in those with inflammatory bowel disease (24.2%).
- TB reactivation risk varies among biologic agents, potentially due to structural/functional differences and tumor necrosis factor (TNF) antagonist kinetics.
Conclusions:
- Psoriasis patients face an elevated TB risk, necessitating careful monitoring during biologic therapy.
- Etanercept may be a preferred anti-TNF agent for TB-high-risk populations due to its kinetics.
- Further research is needed to define TB reactivation risks with other biologics.
Related Concept Videos
01:29Pulmonary Tuberculosis I
1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
01:31Pulmonary Tuberculosis III
1.8K
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
1.8K
01:26Pulmonary Tuberculosis IV
828
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
828
01:28Pulmonary Tuberculosis II
2.5K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.5K
01:28Pulmonary Tuberculosis V
1.0K
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
1.0K
01:27Acne Infection
94
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
94