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Cefdinir.

Abdullah A Al-Badr1, Fahad A Alasseiri1

  • 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|May 6, 2014
PubMed
Summary
This summary is machine-generated.

This comprehensive profile details cefdinir, a third-generation cephalosporin antibiotic. It covers nomenclature, preparation, physical and spectral characteristics, analytical methods, pharmacokinetics, and stability, referencing pharmacopeial monographs.

Keywords:
CefdinirDescriptionMethod of analysisPharmacokineticsPhysical characteristicsSpectral propertiesStabilitySynthesisUses

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Area of Science:

  • Pharmaceutical Chemistry
  • Analytical Chemistry
  • Pharmacology

Background:

  • Cefdinir is a widely used third-generation oral cephalosporin antibiotic.
  • Comprehensive characterization is essential for quality control and therapeutic application.

Purpose of the Study:

  • To provide a detailed profile of cefdinir, encompassing its chemical, physical, spectral, and analytical properties.
  • To outline methods for cefdinir preparation and analysis, referencing established pharmacopeias.

Main Methods:

  • Literature review and compilation of data on cefdinir's nomenclature, formulae, elemental analysis, and physical characteristics (pKa, solubility, DSC, melting point, XRPD).
  • Analysis of spectral data including UV-Vis, IR, NMR (1H, 13C), and Mass Spectrometry.
  • Review of reported analytical methodologies (spectrophotometry, polarography, voltammetry, chromatography) and pharmacokinetics/stability studies.

Main Results:

  • Detailed physical and chemical properties of cefdinir are presented, including spectral data and fragmentation patterns.
  • Pharmacopeial monographs (Japanese and United States) are incorporated.
  • Various analytical techniques for cefdinir determination are summarized, alongside pharmacokinetic and stability data.

Conclusions:

  • This profile serves as a comprehensive resource for cefdinir characterization and analysis.
  • It consolidates essential information for researchers, analysts, and pharmaceutical scientists.
  • The data supports the quality assessment and therapeutic use of cefdinir.