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Ganciclovir.

Abdullah A Al-Badr1, Tariq D S Ajarim1

  • 1College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology
|April 22, 2018
PubMed
Summary
This summary is machine-generated.

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This profile details ganciclovir, a synthetic nucleoside analog with potent anti-cytomegalovirus activity. It covers drug preparation, physical characterization, spectral analysis, and diverse analytical methods for comprehensive understanding.

Area of Science:

  • Pharmaceutical Chemistry
  • Antiviral Drug Development

Background:

  • Ganciclovir is a synthetic nucleoside analog of guanine.
  • It exhibits significant activity against cytomegalovirus (CMV).

Purpose of the Study:

  • To provide a comprehensive profile of ganciclovir.
  • To detail its preparation, characterization, analysis, and biological properties.

Main Methods:

  • Physical characterization: ionization constant, solubility, X-ray diffraction, crystal structure, thermal analysis.
  • Spectroscopic analysis: UV, vibrational, NMR, mass spectrometry.
  • Analytical methods: Compendial (USP), HPLC, LC-MS, electrophoresis, spectrophotometry, voltammetry, chemiluminescence, RIA.

Main Results:

Keywords:
CytomegalovirusDescriptionGanciclovirMetabolismMethods of analysisNomenclaturePharmacokineticsPhysical characteristicsReviewsSpectral propertiesStabilitySynthesisUses

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  • Detailed description of ganciclovir's chemical and physical properties.
  • Outlined preparation methods and characterization techniques.
  • Comprehensive review of analytical methodologies and biological investigations including pharmacokinetics and stability.

    • Conclusions:

    • Ganciclovir's profile is thoroughly presented, encompassing its synthesis, characterization, and analysis.
    • Extensive data on its biological behavior and stability are provided.
    • Over 240 references support the comprehensive nature of this profile.