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Dacarbazine.

Abdullah A Al-Badr¹, Mansour M Alodhaib¹

¹King Saud University, Riyadh, Saudi Arabia.

Profiles of Drug Substances, Excipients, and Related Methodology

|March 5, 2016

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Dacarbazine is an alkylating agent for metastatic melanoma. This monograph details its chemical properties, preparation, physical characterization, spectral data, and analytical methods, including metabolism and stability.

Area of Science:

Pharmacology
Medicinal Chemistry
Analytical Chemistry

Background:

Dacarbazine is a key antineoplastic agent for metastatic malignant melanoma.
It functions as a cell cycle nonspecific alkylating agent.

Purpose of the Study:

To provide a comprehensive monograph on Dacarbazine.
To detail its chemical, physical, spectral, and analytical characteristics.
To review its metabolism, pharmacokinetics, and stability.

Main Methods:

Physical characterization: ionization constant, solubility, X-ray diffraction, crystal structure, melting point, DSC.
Spectroscopic analysis: UV, vibrational, NMR, MS.
Analytical methods: Compendial (USP, BP, Int. Ph.) and advanced techniques (HPLC, HPLC-MS, polarography).

Keywords:

Antineoplastics Dacarbazine Description Metabolism Methods of analysis Nomenclature Physical characteristics Reviews Spectral properties Stability Synthesis Uses

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Main Results:

Detailed chemical and physical properties of Dacarbazine are presented.
Various spectroscopic profiles (UV, vibrational, NMR, MS) are documented.
Established and novel analytical methodologies for Dacarbazine quantification are reviewed.

Conclusions:

This monograph offers a thorough resource on Dacarbazine.
It consolidates information on its properties, analysis, and biological behavior.
Essential for researchers and clinicians working with Dacarbazine.