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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
Notch Signaling Pathway03:14

Notch Signaling Pathway

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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Bone Remodeling and Repair01:31

Bone Remodeling and Repair

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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Related Experiment Video

Updated: Apr 28, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Understanding the role of Notch in osteosarcoma.

Madonna M McManus1, Kurt R Weiss, Dennis P M Hughes

  • 1The Children's Cancer Hospital at MD Anderson Cancer Center, Houston, TX, USA.

Advances in Experimental Medicine and Biology
|June 14, 2014
PubMed
Summary
This summary is machine-generated.

The Notch pathway

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • The Notch pathway's role in osteosarcoma is complex, acting as both an oncogene and potentially a tumor suppressor.
  • Its functions impact cancer cell proliferation, migration, invasiveness, and stemness.
  • Notch signaling is crucial for tumor angiogenesis and vasculogenesis in osteosarcoma.

Purpose of the Study:

  • To elucidate the multifaceted roles of the Notch pathway in osteosarcoma.
  • To understand Notch signaling's interaction with tumor microenvironment components.
  • To explore challenges and future directions in therapeutic targeting of the Notch pathway in osteosarcoma.

Main Methods:

  • Analysis of Notch pathway functions in osteosarcoma cell lines.
  • Investigation of Notch ligand expression in osteosarcoma cells and nonmalignant cells.
  • Review of current and emerging therapeutic strategies targeting the Notch pathway.

Main Results:

  • Notch pathway manipulation affects osteosarcoma cell behaviors like proliferation and migration.
  • Nonmalignant cells, particularly endothelial cells and pericytes, are likely key sources of Notch activation in osteosarcoma.
  • Current therapeutic approaches targeting gamma secretase have limitations due to off-target effects and toxicities.

Conclusions:

  • The Notch pathway's function in osteosarcoma is complex and context-dependent, defying simple oncogene or tumor suppressor classification.
  • Understanding Notch signaling in the tumor microenvironment is critical for effective therapeutic strategies.
  • Future research should focus on novel therapeutic targets downstream of Notch signaling for improved osteosarcoma treatment.