Dysfunction of affective network in post ischemic stroke depression: a resting-state functional magnetic resonance
Peiyao Zhang1, Qin Xu2, Jianping Dai1
1Department of Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing 100050, China.
Biomed Research International
|June 26, 2014
Summary
Poststroke depression (PSD) is linked to altered affective network (AN) functional connectivity (FC). This study found disrupted AN FC in PSD patients, correlating with depression severity, suggesting AN dysfunction contributes to PSD.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Poststroke depression (PSD) is a common complication following stroke.
- Stroke characteristics and psychosocial factors are known contributors to PSD development.
Purpose of the Study:
- To identify altered functional connectivity (FC) within the affective network (AN) in patients with PSD.
- To investigate the relationship between AN FC and the severity of PSD.
Main Methods:
- Resting-state functional MRI (fMRI) was performed on 26 PSD patients, 24 stroke patients without depression, and 24 healthy controls.
- Bilateral anterior cingulated cortices (ACCs) were used as regions of interest (ROIs) to calculate FC.
- FC differences among groups were analyzed, and correlations with Hamilton Depression Rate Scale (HDRS) scores in PSD patients were examined.
Main Results:
- PSD patients exhibited disrupted FC of the AN compared to both stroke patients without depression and normal controls.
- Altered FC in the left orbital part of the inferior frontal gyrus was significantly correlated with HDRS scores in PSD patients.
Conclusions:
- Functional connectivity disruptions in the affective network are implicated in the development of poststroke depression.
- Affective network dysfunction may be a key factor contributing to PSD pathophysiology.
