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Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
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Dexmedetomidine for infant pulmonary function testing.

Patrick Callahan1, Swaroop J Pinto, Geoffrey Kurland

  • 1Departments of Anesthesiology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Pediatric Pulmonology
|September 5, 2014
PubMed
Summary
This summary is machine-generated.

Oral chloral hydrate, a long-standing sedative for infant lung function tests, is now scarce. Intravenous dexmedetomidine (DMED) is explored as a potential alternative with minimal impact on pulmonary function.

Keywords:
infant pulmonary functionpulmonary function testing (PFT)

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Area of Science:

  • Pediatric Pulmonology
  • Clinical Pharmacology
  • Anesthesiology

Background:

  • Oral chloral hydrate has been the standard sedative for infant lung function testing for 30 years.
  • Manufacturing of chloral hydrate was discontinued in 2012, leading to severe shortages.
  • Alternative sedatives like midazolam and propofol have been proposed due to chloral hydrate scarcity.

Purpose of the Study:

  • To evaluate the feasibility and effects of intravenous dexmedetomidine (DMED) as a sedative for infant lung function testing.
  • To address the clinical need for alternative sedatives amid chloral hydrate shortages.

Main Methods:

  • Describes limited clinical experience with intravenous dexmedetomidine (DMED) in infants undergoing lung function testing.
  • Focuses on the medication's administration and observed effects.

Main Results:

  • Dexmedetomidine (DMED) has been preliminarily described as having minimal impact on pulmonary function.
  • Further investigation is needed to confirm its safety and efficacy in this specific application.

Conclusions:

  • Intravenous dexmedetomidine (DMED) presents a potential alternative for infant sedation during lung function tests.
  • Its minimal effect on respiratory drive warrants further research for clinical application.