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Hereditary Thrombophilic Factors in Glaucoma
Mehmet A Sekeroglu1, Murat Irkec, Mehmet C Mocan
1*Ulucanlar Eye Training and Research Hospital †Department of Ophthalmology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Journal of Glaucoma
|September 30, 2014
Summary
This study found no significant differences in hereditary thrombophilic factors between patients with primary open-angle glaucoma, exfoliative glaucoma, exfoliation syndrome, and healthy individuals. Inherited prothrombotic risk factors do not appear to be associated with these glaucoma types.
Area of Science:
- Ophthalmology
- Genetics
- Hematology
Background:
- Glaucoma encompasses a group of optic neuropathies often associated with elevated intraocular pressure.
- Exfoliation syndrome is a condition characterized by the production and deposition of abnormal fibrillar extracellular material.
- Hereditary thrombophilic factors are genetic predispositions to blood clot formation.
Purpose of the Study:
- To investigate the prevalence of hereditary thrombophilic factors in patients diagnosed with primary open-angle glaucoma, exfoliative glaucoma, and exfoliation syndrome.
- To compare these findings with those observed in a healthy control group.
Main Methods:
- The study enrolled 75 patients across three groups: primary open-angle glaucoma (n=25), exfoliative glaucoma (n=25), and exfoliation syndrome (n=25), along with 25 healthy controls.
- Genetic analysis was performed for methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation, prothrombin G20210A mutation, and factor V Leiden mutation.
- Blood tests measured activated protein C resistance, protein S, protein C, antithrombin III activities, and homocysteine levels.
Main Results:
- No statistically significant differences were found in the mean age or sex distribution among the study groups.
- Levels of homocysteine, folate, vitamin B12, antithrombin III activity, protein C activity, free protein S activity, and activated protein C resistance did not differ significantly between groups.
- The frequency of MTHFR C677T, prothrombin G20210A, and factor V Leiden mutations was similar across all study groups.
Conclusions:
- The study concludes that there are no significant differences in inherited prothrombotic risk factors between patients with glaucoma (primary open-angle, exfoliative) and exfoliation syndrome compared to healthy individuals.
- These findings suggest that common hereditary thrombophilic factors are unlikely to be a significant risk factor for the development of these specific types of glaucoma.
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