Related Experiment Video
Updated: Apr 22, 2026

Osteoclast Derivation from Mouse Bone Marrow
Published on: November 6, 2014
[Gelatinous transformation of the bone marrow caused by excessive physical activity and insufficient calorie intake]
Steven A W Andersen1, Louise Salomo, Elisabeth Ralfkiær
1Hæmatologisk Klinik, Finsencentret, Rigshospitalet, Blegdamsvej 9, 2100 København Ø.
Abstract:
Gelatinous transformation (GT) of the bone marrow is rare and associated with a variety of clinical diseases from malignancy to chronic infection in combination with malnutrition or wasting. A new clinical picture of GT has emerged with excessive physical activity in combination with a voluntary insufficient calorie intake in the young adult male. Overtraining syndrome and systemic inflammation may play a role in the pathogenesis of GT in these patients, but further studies on GT and the effect of training and overtraining on the bone marrow are needed.
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