[Wilson disease often debuts with psychiatric symptoms]

Area of Science:

• Neurology
• Genetics
• Psychiatry

Background:

• Wilson disease is a rare autosomal recessive genetic disorder.
• It causes copper accumulation in organs like the liver, brain, and eyes.
• Neurological and psychiatric symptoms can be the primary presentation.

Observation:

• A 17-year-old female presented with symptoms initially suggestive of an affective psychiatric disorder.
• Repeated physical examinations and paraclinical testing were crucial for accurate diagnosis.
• The patient's overall symptomatology guided the diagnostic process.

Findings:

• The patient was ultimately diagnosed with Wilson disease.
• This diagnosis was reached after ruling out primary psychiatric conditions.
• The case underscores the varied clinical manifestations of Wilson disease.

Implications:

• A broad diagnostic approach is essential for patients with apparent psychiatric conditions.
• Early and accurate diagnosis of Wilson disease can prevent severe complications.
• Interdisciplinary collaboration between neurology, psychiatry, and genetics is vital.