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Updated: Apr 21, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
[Serious bleeding as a consequence of accumulation of dabigatran caused by renal failure]
Anne Mette Skjødt-Jensen1, Anne-Mette Hvas
1Anæstesiologisk-intensiv Afdeling I, Aarhus Universitetshospital, Brendstrupgårdsvej 100, 8200 Aarhus N. anneskjo@rm.dk.
Abstract:
A 77-year-old male was hospitalized due to haematuria and developed septicaemia. He received dabigatran due to chronic atrial fibrillation. Doses were reduced because of renal failure according to guidelines. The patient showed extensive changes in his entire coagulation system. Due to renal failure forced diuresis was not possible, and continuous dialysis was performed. Patients with renal failure should be monitored closely - if there are any sign of bleeding it is important to consider change of anticoagulant therapy as long as an antidote does not exist.
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